AskDefine | Define permissive

Dictionary Definition

permissive adj
1 not preventive [ant: preventive]
2 granting or inclined or able to grant permission; not strict in discipline; "direct primary legislation is largely permissive rather than prescriptive"; "permissive parents" [ant: unpermissive]

User Contributed Dictionary

English

Adjective

  1. Giving, or predisposed to give permission; lenient.

Translations

lenient

Anagrams

Italian

Adjective

permissive
  1. Feminine plural form of permissivo

Extensive Definition

When a cell or host is defined as permissive in virology, it refers to the fact that the virus is able to circumvent host defenses and is able to replicate. Usually this occurs when the virus has modulated one or several of the host cellular intrinsic defenses, and the host immune system. The permissive state of a host has now been determined to be the primary factor in determining whether a virus will cause pathological symptoms in a host.

Susceptible versus Permissive

The significance between the difference of the two has now been elucidated with study of the rabbit-lethal myxoma virus. Many species of rabbit cells in culture (without the presence of any antiviral defenses that would normally be in a host) can be infected by the myxoma virus, causing infection and cell death. However, inoculation of the myxoma virus in many species of rabbit shows that only one species of rabbit is affected, the rest being completely unharmed by the virus (lack of even viral shedding). This has been determined to be a result of the myxoma virus's inability to suppress other species' interferon expression, and hence resulting in the interferon in turn suppressing the myxoma virus.
This is a result of the positive susceptibility of many species of rabbit's cells, but negative permissibility of all but one of the rabbit species' cells.

Literature

Synonyms, Antonyms and Related Words

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